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Niels Bovenschen Selected Research

Granzymes (Granzyme)

1/2021Intracellular expression of granzymes A, B, K and M in blood lymphocyte subsets of critically ill patients with or without sepsis.
1/2021Noncytotoxic functions of killer cell granzymes in viral infections.
3/2020Increased intra-articular granzyme M may trigger local IFN-λ1/IL-29 response in rheumatoid arthritis.
1/2020Killer cell proteases can target viral immediate-early proteins to control human cytomegalovirus infection in a noncytotoxic manner.
1/2020Modulation of Inflammation by Extracellular Granzyme A.
1/2018Prognostic relevance of tumor-infiltrating lymphocytes and immune checkpoints in pediatric medulloblastoma.
12/2017Systemic and local granzyme B levels are associated with disease activity, kidney damage and interferon signature in systemic lupus erythematosus.
5/2016Oropharyngeal squamous cell carcinomas differentially express granzyme inhibitors.
1/2016Granzyme M and K release in human experimental endotoxemia.
1/2016Granzymes A and K differentially potentiate LPS-induced cytokine response.
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Niels Bovenschen Research Topics

Disease

20Neoplasms (Cancer)
10/2021 - 04/2006
7Inflammation (Inflammations)
01/2021 - 05/2010
5Infections
01/2021 - 01/2014
2Brain Neoplasms (Brain Tumor)
10/2021 - 01/2016
2Medulloblastoma
10/2021 - 01/2018
2Sepsis (Septicemia)
01/2021 - 04/2014
2Autoimmune Diseases (Autoimmune Disease)
03/2020 - 04/2014
2Diabetic Nephropathies (Diabetic Nephropathy)
10/2017 - 11/2008
2Squamous Cell Carcinoma (Epidermoid Carcinoma)
05/2016 - 03/2016
2Protein Deficiency
05/2004 - 05/2003
1Lung Neoplasms (Lung Cancer)
10/2021
1Melanoma (Melanoma, Malignant)
10/2021
1Colorectal Neoplasms (Colorectal Cancer)
01/2021
1Virus Diseases (Viral Diseases)
01/2021
1Critical Illness (Critically Ill)
01/2021
1Rheumatoid Arthritis
03/2020
1Cytomegalovirus Infections (Inclusion Disease)
01/2020
1Persistent Infection
01/2018
1Kidney Diseases (Kidney Disease)
01/2018
1Chronic Kidney Failure (Chronic Renal Failure)
01/2018
1Proteinuria
12/2017
1Systemic Lupus Erythematosus (Libman-Sacks Disease)
12/2017
1Fibrosis (Cirrhosis)
10/2017
1Primitive Neuroectodermal Tumors (PNET)
01/2016
1Endotoxemia
01/2016
1Multiple Myeloma
10/2013
1Cardiomyopathies (Cardiomyopathy)
07/2013
1Dilated Cardiomyopathy (Cardiomyopathy, Congestive)
05/2011
1Heart Failure
05/2011
1Myocardial Ischemia (Ischemic Heart Diseases)
05/2011
1Squamous Cell Carcinoma of Head and Neck
10/2009
1Lymphatic Metastasis
10/2009
1Neuroendocrine Tumors (Neuroendocrine Tumor)
05/2009
1Islet Cell Adenoma (Islet Cell Tumors)
05/2009
1Albuminuria
11/2008
1Carcinogenesis
04/2006
1Hypoxia (Hypoxemia)
04/2006
1Atherosclerosis
05/2004

Drug/Important Bio-Agent (IBA)

21Granzymes (Granzyme)IBA
01/2021 - 06/2008
7Proteins (Proteins, Gene)FDA Link
01/2021 - 04/2006
7Serine Proteases (Serine Protease)IBA
01/2021 - 06/2008
3Peptide Hydrolases (Proteases)FDA Link
01/2021 - 08/2011
2PerforinIBA
01/2021 - 06/2008
2InterferonsIBA
01/2020 - 12/2017
2Connective Tissue Growth FactorIBA
10/2017 - 11/2008
2Biological ProductsIBA
10/2016 - 03/2016
2AntibodiesIBA
01/2016 - 10/2009
2SerpinsIBA
01/2016 - 01/2011
2Serine Proteinase Inhibitors (Serine Protease Inhibitors)IBA
01/2011 - 05/2009
2Messenger RNA (mRNA)IBA
10/2009 - 11/2008
2LDL Receptors (LDL Receptor)IBA
05/2004 - 05/2003
1Immediate-Early ProteinsIBA
01/2020
1Viral ProteinsIBA
01/2020
1Histocompatibility Antigens Class IIBA
01/2018
1HLA Antigens (Human Leukocyte Antigens)IBA
01/2018
1CreatinineIBA
12/2017
1Vascular Endothelial Growth Factor CIBA
10/2017
1Immunoglobulin A (IgA)IBA
01/2016
1CytokinesIBA
01/2015
1Caspase 3 (Caspase-3)IBA
10/2013
1LuciferasesIBA
10/2013
1SurvivinIBA
10/2013
1Bortezomib (Velcade)FDA Link
10/2013
1MicroRNAs (MicroRNA)IBA
07/2013
1Reactive Oxygen Species (Oxygen Radicals)IBA
06/2012
1CaspasesIBA
06/2012
1Heterogeneous-Nuclear Ribonucleoprotein KIBA
06/2012
1Protease Inhibitors (Protease Inhibitor)IBA
10/2009
1Chromogranin AIBA
05/2009
1SynaptophysinIBA
05/2009
1Matrix Metalloproteinases (MMPs)IBA
11/2008
1Bone Morphogenetic Protein 7IBA
11/2008
1TubulinIBA
06/2008
1ezrinIBA
06/2008
1ProteomeIBA
06/2008
1Single-Domain AntibodiesIBA
04/2006
1Transcription Factors (Transcription Factor)IBA
04/2006
1CholesterolIBA
05/2004
1Lipoproteins (Lipoprotein)IBA
05/2004
1LigandsIBA
05/2004
1Apolipoproteins E (ApoE)IBA
05/2004
1Factor VIII (Coagulation Factor VIII)IBA
05/2003

Therapy/Procedure

6Therapeutics
10/2021 - 01/2016
5Immunotherapy
10/2021 - 10/2013
2Drug Therapy (Chemotherapy)
10/2021 - 11/2017
1Immunomodulation
01/2018
1Kidney Transplantation
01/2018
1Transplantation
01/2018
1Radiotherapy
11/2017
1Particle Accelerators
10/2016
1Heart-Assist Devices
05/2011
1Heart Transplantation (Grafting, Heart)
05/2011